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KMID : 0882420140870010042
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Korean Journal of Medicine
2014 Volume.87 No. 1 p.42 ~ p.52
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Vascular Calcification Scores are Associated with Arterial Stiffness, Inflammation, and Nutrition in Hemodialysis Patients
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Shin Sun-Young
Han Kyu-Hyun
Jeong Hye-Yun
Chu Ji-Min
Kim Hong-Min
Suh Seong-Eun
Hyun Yu-Kyung
Kim Hyung-Jong
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Abstract
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Background/Aims: The vascular calcification (VC) score on a plain X-ray is associated with cardiovascular disease and mortality in hemodialysis (HD) patients. This study examined the correlations among the VC scores for the hands and pelvis X-rays, arterial stiffness, inflammation, and nutrition in HD patients.
Method: VC was evaluated using plain x-rays of the hands and pelvis. Patients were categorized into the VC (+) (VC score ≥ 3) or VC (-) (VC score < 3) groups. We measured the pulse wave velocity (PWV), ankle brachial index (ABI), and augmentation index (AI).
Results: The mean age of the patients was 55.6 ± 13.2 years. The prevalence of diabetes mellitus (DM) was significantly higher in the VC (+) group than in the VC (-) group (87.5 vs. 34.2%, p < 0.05). The serum PTH (98.4 ± 141.9 vs. 183.6 ± 231.3 pg/mL, p < 0.05) and albumin (3.7 ± 0.5 vs. 3.9 ± 0.3 g/dL, p < 0.05) levels were significantly lower and PWV was significantly (p < 0.05) higher in the VC (+) group. In multiple linear regression analysis, only the presence of diabetes mellitus was significantly related to the VC score.
Conclusions: The VC score was associated with the serum PTH and albumin, as well as with vascular stiffness. C-reactive protein did not show any significant association with the VC score.
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KEYWORD
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Vascular calcification, Vascular stiffness, Pulse wave analysis, Hemodialysis
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